OXIMES AND ATROPINE IN SARIN POISONING

Atropine poisoning mimicking septicemia

A young female was admitted in medical emergency room with fever, tachycardia and breathing difficulty. A provisional diagnosis of septicemia was made and empirical antibiotics were started. The patient required intubation and assisted ventilation. The patient recovered within 72 hours completely except bilateral mid-dilated fixed pupils. Atropine was not administered in the hospital. All blood...

An outbreak of atropine poisoning.

FiFTEEN men, all Royal Air Force personnel, varying in age from nineteen to forty-two years, but mainly in the early twenties, were given a period of prolonged narcosis intended to last ten days in each case. They were all in satisfactory physical health but suffered from psychoneuroses. The technique of treatment was a modification of that advocated by Brody (1940) for restless, older patients...

Pharmacokinetic Studies on Oximes in Organophosphate Poisoning: A Mini Review

Organophosphate (OP) poisoning is one of the most common causes of poisoning in developing countries especially in Southeastern Asia. Poisoning with phosphorus-containing organic chemicals or OP compounds can be managed with antidotes like oximes which are potential reactivators of acetylcholinesterase (AChE). The efficacy of oxime therapy in OP poisoned patients mainly depends upon various fac...

[Efficacy of several oximes on organophosphorus poisoning].

Various organophosphorus compounds, particularly those with low acute toxicity levels, such as Fenitrothion (common name; Sumithion), Fenthion (common name; Baycid) and Pyridaphenthion (common name; Ofunack), are widely used as insecticides around the world. PAM (2-Pyridinum aldoxime methiodide), the specific antidote against Parathion, is not very effective against poisoning by these organopho...

High dose atropine in organophosphorus poisoning.